ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

POZ-, AT hook-, and zinc finger-containing protein 1

Intramolecular
Cysteine 357 and cysteine 360
Cysteine 294 and cysteine 297
Cysteine 415 and cysteine 418
Cysteine 385 and cysteine 388
A redox-regulated disulphide may form within POZ-, AT hook-, and zinc finger-containing protein 1 between cysteines 357 and 360.

Details

Redox score ?
88
PDB code
2epr
Structure name
solution structure of the secound zinc finger domain of zinc finger protein 278
Structure deposition date
2007-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
7
% buried
0
Peptide accession
Q9HBE1
Residue number A
357
Residue number B
360
Peptide name
POZ-, AT hook-, and zinc finger-containing protein 1

Ligandability

Cysteine 357 of POZ-, AT hook-, and zinc finger-containing protein 1

Cysteine 360 of POZ-, AT hook-, and zinc finger-containing protein 1

A redox-regulated disulphide may form within POZ-, AT hook-, and zinc finger-containing protein 1 between cysteines 294 and 297.

Details

Redox score ?
86
PDB code
2epp
Structure name
solution structure of the first c2h2 type zinc finger domain of zinc finger protein 278
Structure deposition date
2007-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
8
% buried
0
Peptide accession
Q9HBE1
Residue number A
294
Residue number B
297
Peptide name
POZ-, AT hook-, and zinc finger-containing protein 1

Ligandability

Cysteine 294 of POZ-, AT hook-, and zinc finger-containing protein 1

Cysteine 297 of POZ-, AT hook-, and zinc finger-containing protein 1

A redox-regulated disulphide may form within POZ-, AT hook-, and zinc finger-containing protein 1 between cysteines 415 and 418.

Details

Redox score ?
85
PDB code
2eps
Structure name
solution structure of the 4th zinc finger domain of zinc finger protein 278
Structure deposition date
2007-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
Q9HBE1
Residue number A
415
Residue number B
418
Peptide name
POZ-, AT hook-, and zinc finger-containing protein 1

Ligandability

Cysteine 415 of POZ-, AT hook-, and zinc finger-containing protein 1

Cysteine 418 of POZ-, AT hook-, and zinc finger-containing protein 1

A redox-regulated disulphide may form within POZ-, AT hook-, and zinc finger-containing protein 1 between cysteines 385 and 388.

Details

Redox score ?
85
PDB code
2epq
Structure name
solution structure of the third zinc finger domain of zinc finger protein 278
Structure deposition date
2007-03-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
38
Minimum pKa ?
8
% buried
0
Peptide accession
Q9HBE1
Residue number A
385
Residue number B
388
Peptide name
POZ-, AT hook-, and zinc finger-containing protein 1

Ligandability

Cysteine 385 of POZ-, AT hook-, and zinc finger-containing protein 1

Cysteine 388 of POZ-, AT hook-, and zinc finger-containing protein 1

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