MAP kinase-interacting serine/threonine-protein kinase 2
Intramolecular
Cysteine 299 and cysteine 311
Cysteine 303 and cysteine 314
Cysteine 311 and cysteine 314
Cysteine 299 and cysteine 314
Cysteine 303 and cysteine 311
Cysteine 299 and cysteine 42
Cysteine 299 and cysteine 303
Cysteine 42 and cysteine 311
Cysteine 42 and cysteine 314
2ac5 A 299 A 311
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 299 and 311.
Details
Redox score ?
92
PDB code
2ac5
Structure name
structure of human mnk2 kinase domain mutant d228g
Structure deposition date
2005-07-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
6
% buried
0
Peptide accession
Q9HBH9
Residue number A
299
Residue number B
311
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 299 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 311 of MAP kinase-interacting serine/threonine-protein kinase 2
2ac3 A 303 A 314
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 303 and 314.
Details
Redox score ?
89
PDB code
2ac3
Structure name
structure of human mnk2 kinase domain
Structure deposition date
2005-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
6
% buried
0
Peptide accession
Q9HBH9
Residue number A
303
Residue number B
314
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 303 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 314 of MAP kinase-interacting serine/threonine-protein kinase 2
2ac5 A 311 A 314
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 311 and 314.
Details
Redox score ?
89
PDB code
2ac5
Structure name
structure of human mnk2 kinase domain mutant d228g
Structure deposition date
2005-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
39
Minimum pKa ?
6
% buried
0
Peptide accession
Q9HBH9
Residue number A
311
Residue number B
314
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 311 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 314 of MAP kinase-interacting serine/threonine-protein kinase 2
2ac5 A 299 A 314
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 299 and 314.
Details
Redox score ?
87
PDB code
2ac5
Structure name
structure of human mnk2 kinase domain mutant d228g
Structure deposition date
2005-07-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
0
Peptide accession
Q9HBH9
Residue number A
299
Residue number B
314
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 299 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 314 of MAP kinase-interacting serine/threonine-protein kinase 2
2ac3 A 303 A 311
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 303 and 311.
Details
Redox score ?
86
PDB code
2ac3
Structure name
structure of human mnk2 kinase domain
Structure deposition date
2005-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
8
% buried
0
Peptide accession
Q9HBH9
Residue number A
303
Residue number B
311
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 303 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 311 of MAP kinase-interacting serine/threonine-protein kinase 2
6ck6 A 299 A 303
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 299 and 42 (299 and 303 respectively in this structure).
Details
Redox score ?
83
PDB code
6ck6
Structure name
crystal structure of mnk2-d228g in complex with inhibitor
Structure deposition date
2018-02-27
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
0
Peptide accession
Q9HBH9
Residue number A
299
Residue number B
42
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 299 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 42 of MAP kinase-interacting serine/threonine-protein kinase 2
2ac3 A 299 A 303
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 299 and 303.
Details
Redox score ?
82
PDB code
2ac3
Structure name
structure of human mnk2 kinase domain
Structure deposition date
2005-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
9
% buried
0
Peptide accession
Q9HBH9
Residue number A
299
Residue number B
303
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 299 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 303 of MAP kinase-interacting serine/threonine-protein kinase 2
2hw7 A 303 A 311
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 42 and 311 (303 and 311 respectively in this structure).
Details
Redox score ?
79
PDB code
2hw7
Structure name
crystal structure of mnk2-d228g in complex with staurosporine
Structure deposition date
2006-08-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
nan
Peptide accession
Q9HBH9
Residue number A
42
Residue number B
311
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 42 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 311 of MAP kinase-interacting serine/threonine-protein kinase 2
2hw7 A 303 A 314
A redox-regulated disulphide may form within MAP kinase-interacting serine/threonine-protein kinase 2 between cysteines 42 and 314 (303 and 314 respectively in this structure).
Details
Redox score ?
73
PDB code
2hw7
Structure name
crystal structure of mnk2-d228g in complex with staurosporine
Structure deposition date
2006-08-01
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
nan
Peptide accession
Q9HBH9
Residue number A
42
Residue number B
314
Peptide name
MAP kinase-interacting serine/threonine-protein kinase 2
Ligandability
Cysteine 42 of MAP kinase-interacting serine/threonine-protein kinase 2
Cysteine 314 of MAP kinase-interacting serine/threonine-protein kinase 2
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