ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sentrin-specific protease 2

Intramolecular
Cysteine 490 and cysteine 505
Cysteine 548 and cysteine 553
A redox-regulated disulphide may form within Sentrin-specific protease 2 between cysteines 490 and 505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5aek
Structure name
crystal structure of the human senp2 c548s in complex with the human sumo1 k48m f66w
Structure deposition date
2014-12-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
48
Peptide accession
Q9HC62
Residue number A
490
Residue number B
505
Peptide name
Sentrin-specific protease 2

Ligandability

Cysteine 490 of Sentrin-specific protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of Sentrin-specific protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sentrin-specific protease 2 between cysteines 548 and 553. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
1tgz
Structure name
structure of human senp2 in complex with sumo-1
Structure deposition date
2004-05-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
92
Peptide accession
Q9HC62
Residue number A
548
Residue number B
553
Peptide name
Sentrin-specific protease 2

Ligandability

Cysteine 548 of Sentrin-specific protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 553 of Sentrin-specific protease 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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