ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytokine receptor-like factor 2

Intramolecular
Cysteine 180 and cysteine 218
Cysteine 71 and cysteine 84
Cysteine 138 and cysteine 168
Cysteine 208 and cysteine 218
Cysteine 180 and cysteine 208
A redox-regulated disulphide may form within Cytokine receptor-like factor 2 between cysteines 180 and 218.

Details

Redox score ?
88
PDB code
5j12
Structure name
structure of human tslp:tslpr in complex with mouse il-7ralpha
Structure deposition date
2016-03-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HC73
Residue number A
180
Residue number B
218
Peptide name
Cytokine receptor-like factor 2

Ligandability

Cysteine 180 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor-like factor 2 between cysteines 71 and 84.

Details

Redox score ?
86
PDB code
5j11
Structure name
structure of human tslp in complex with tslpr and il-7ralpha
Structure deposition date
2016-03-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HC73
Residue number A
71
Residue number B
84
Peptide name
Cytokine receptor-like factor 2

Ligandability

Cysteine 71 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor-like factor 2 between cysteines 138 and 168.

Details

Redox score ?
86
PDB code
5j12
Structure name
structure of human tslp:tslpr in complex with mouse il-7ralpha
Structure deposition date
2016-03-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HC73
Residue number A
138
Residue number B
168
Peptide name
Cytokine receptor-like factor 2

Ligandability

Cysteine 138 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor-like factor 2 between cysteines 208 and 218.

Details

Redox score ?
73
PDB code
5j11
Structure name
structure of human tslp in complex with tslpr and il-7ralpha
Structure deposition date
2016-03-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9HC73
Residue number A
208
Residue number B
218
Peptide name
Cytokine receptor-like factor 2

Ligandability

Cysteine 208 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine receptor-like factor 2 between cysteines 180 and 208.

Details

Redox score ?
67
PDB code
5j12
Structure name
structure of human tslp:tslpr in complex with mouse il-7ralpha
Structure deposition date
2016-03-28
Thiol separation (Å)
5
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
nan
Peptide accession
Q9HC73
Residue number A
180
Residue number B
208
Peptide name
Cytokine receptor-like factor 2

Ligandability

Cysteine 180 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Cytokine receptor-like factor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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