G-protein coupled receptor 35
Intramolecular
Cysteine 89 and cysteine 162
Cysteine 46 and cysteine 47
Cysteine 68 and cysteine 71
Cysteine 269 and cysteine 270
Cysteine 229 and cysteine 275
Cysteine 229 and cysteine 270
Cysteine 229 and cysteine 269
Cysteine 68 and cysteine 269
8h8j C 89 C 162
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 89 and 162.
Details
Redox score ?
85
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HC97
Residue number A
89
Residue number B
162
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 89 of G-protein coupled receptor 35
Cysteine 162 of G-protein coupled receptor 35
8h8j C 46 C 47
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 46 and 47.
Details
Redox score ?
62
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
41
Minimum pKa ?
9
% buried
14
Peptide accession
Q9HC97
Residue number A
46
Residue number B
47
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 46 of G-protein coupled receptor 35
Cysteine 47 of G-protein coupled receptor 35
8h8j C 68 C 71
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 68 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
36
Peptide accession
Q9HC97
Residue number A
68
Residue number B
71
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 68 of G-protein coupled receptor 35
Cysteine 71 of G-protein coupled receptor 35
8h8j C 269 C 270
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 269 and 270. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
82
Peptide accession
Q9HC97
Residue number A
269
Residue number B
270
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 269 of G-protein coupled receptor 35
Cysteine 270 of G-protein coupled receptor 35
8h8j C 229 C 275
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 229 and 275. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
64
Peptide accession
Q9HC97
Residue number A
229
Residue number B
275
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 229 of G-protein coupled receptor 35
Cysteine 275 of G-protein coupled receptor 35
8h8j C 229 C 270
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 229 and 270. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
71
Peptide accession
Q9HC97
Residue number A
229
Residue number B
270
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 229 of G-protein coupled receptor 35
Cysteine 270 of G-protein coupled receptor 35
8h8j C 229 C 269
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 229 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
88
Peptide accession
Q9HC97
Residue number A
229
Residue number B
269
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 229 of G-protein coupled receptor 35
Cysteine 269 of G-protein coupled receptor 35
8h8j C 68 C 269
A redox-regulated disulphide may form within G-protein coupled receptor 35 between cysteines 68 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
8h8j
Structure name
lodoxamide-bound gpr35 in complex with g13
Structure deposition date
2022-10-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
75
Peptide accession
Q9HC97
Residue number A
68
Residue number B
269
Peptide name
G-protein coupled receptor 35
Ligandability
Cysteine 68 of G-protein coupled receptor 35
Cysteine 269 of G-protein coupled receptor 35
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