a tool for identifying drug-targetable redox-active disulphides

Single chain Fv

Intramolecular

Cysteine 22 and cysteine 96

A redox-regulated disulphide may form within Single chain Fv between cysteines 22 and 96 (22 and 92 respectively in this structure).

Details

Redox score ?

80

PDB code

Structure name

crystal structure of a human vh domain

Structure deposition date

2004-04-21

Thiol separation (Å)

2

Half-sphere exposure sum ?

87

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

22

Residue number B

96

Peptide name

Single chain Fv

Ligandability

Cysteine 22 of Single chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Single chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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