a tool for identifying drug-targetable redox-active disulphides

Nuclear receptor coactivator 5

Intramolecular

Cysteine 200 and cysteine 266

A redox-regulated disulphide may form within Nuclear receptor coactivator 5 between cysteines 200 and 266 (11 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

solution structure of anticodon binding domain from nuclear receptor coactivator 5 (human kiaa1637 protein)

Structure deposition date

2004-01-20

Thiol separation (Å)

8

Half-sphere exposure sum ?

84

Minimum pK_a ?

11

% buried

90

Peptide accession

Residue number A

200

Residue number B

266

Peptide name

Nuclear receptor coactivator 5

Ligandability

Cysteine 200 of Nuclear receptor coactivator 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Nuclear receptor coactivator 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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