ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pre-mRNA-splicing factor CWC22 homolog

Intramolecular
Cysteine 274 and cysteine 300
Cysteine 490 and cysteine 515 L
Cysteine 496 and cysteine 497 L
Cysteine 472 and cysteine 496 L
A redox-regulated disulphide may form within Pre-mRNA-splicing factor CWC22 homolog between cysteines 274 and 300.

Details

Redox score ?
69
PDB code
4c9b
Structure name
crystal structure of eif4aiii-cwc22 complex
Structure deposition date
2013-10-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
91
Minimum pKa ?
9
% buried
100
Peptide accession
Q9HCG8
Residue number A
274
Residue number B
300
Peptide name
Pre-mRNA-splicing factor CWC22 homolog

Ligandability

Cysteine 274 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 300 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor CWC22 homolog between cysteines 490 and 515. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
81
Peptide accession
Q9HCG8
Residue number A
490
Residue number B
515
Peptide name
Pre-mRNA-splicing factor CWC22 homolog

Ligandability

Cysteine 490 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 515 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor CWC22 homolog between cysteines 496 and 497. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6icz
Structure name
cryo-em structure of a human post-catalytic spliceosome (p complex) at 3
Structure deposition date
2018-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
100
Peptide accession
Q9HCG8
Residue number A
496
Residue number B
497
Peptide name
Pre-mRNA-splicing factor CWC22 homolog

Ligandability

Cysteine 496 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 497 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor CWC22 homolog between cysteines 472 and 496. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7dvq
Structure name
cryo-em structure of the activated human minor spliceosome (minor bact complex)
Structure deposition date
2021-01-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
100
Peptide accession
Q9HCG8
Residue number A
472
Residue number B
496
Peptide name
Pre-mRNA-splicing factor CWC22 homolog

Ligandability

Cysteine 472 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 496 of Pre-mRNA-splicing factor CWC22 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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