ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Roundabout homolog 2

Intramolecular
Cysteine 439 and cysteine 488
Cysteine 154 and cysteine 203
Cysteine 246 and cysteine 293
Cysteine 335 and cysteine 391
Cysteine 52 and cysteine 110
A redox-regulated disulphide may form within Roundabout homolog 2 between cysteines 439 and 488.

Details

Redox score ?
83
PDB code
6iaa
Structure name
hrobo2 ectodomain
Structure deposition date
2018-11-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCK4
Residue number A
439
Residue number B
488
Peptide name
Roundabout homolog 2

Ligandability

Cysteine 439 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 488 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 2 between cysteines 154 and 203.

Details

Redox score ?
83
PDB code
6iaa
Structure name
hrobo2 ectodomain
Structure deposition date
2018-11-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCK4
Residue number A
154
Residue number B
203
Peptide name
Roundabout homolog 2

Ligandability

Cysteine 154 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 203 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 2 between cysteines 246 and 293.

Details

Redox score ?
82
PDB code
6i9s
Structure name
hrobo2 extracellular domains 2-3
Structure deposition date
2018-11-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCK4
Residue number A
246
Residue number B
293
Peptide name
Roundabout homolog 2

Ligandability

Cysteine 246 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 293 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 2 between cysteines 335 and 391.

Details

Redox score ?
82
PDB code
6iaa
Structure name
hrobo2 ectodomain
Structure deposition date
2018-11-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCK4
Residue number A
335
Residue number B
391
Peptide name
Roundabout homolog 2

Ligandability

Cysteine 335 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 391 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Roundabout homolog 2 between cysteines 52 and 110.

Details

Redox score ?
82
PDB code
6iaa
Structure name
hrobo2 ectodomain
Structure deposition date
2018-11-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCK4
Residue number A
52
Residue number B
110
Peptide name
Roundabout homolog 2

Ligandability

Cysteine 52 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Roundabout homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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