a tool for identifying drug-targetable redox-active disulphides

Protocadherin-18

Intramolecular

Cysteine 98 and cysteine 104

A redox-regulated disulphide may form within Protocadherin-18 between cysteines 98 and 104 (71 and 77 respectively in this structure).

Details

Redox score ?

86

PDB code

Structure name

crystal structure of human protocadherin 18 ec1-ec4

Structure deposition date

2020-01-06

Thiol separation (Å)

2

Half-sphere exposure sum ?

50

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

98

Residue number B

104

Peptide name

Protocadherin-18

Ligandability

Cysteine 98 of Protocadherin-18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Protocadherin-18

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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