ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Glycerol-3-phosphate acyltransferase 1, mitochondrial

Intramolecular
Cysteine 623 and cysteine 643
A redox-regulated disulphide may form within Glycerol-3-phosphate acyltransferase 1, mitochondrial between cysteines 623 and 643.

Details

Redox score ?
74
PDB code
8e50
Structure name
cryo-em structure of human glycerol-3-phosphate acyltransferase 1 (gpat1) in complex with coa and palmitoyl-lpa
Structure deposition date
2022-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
8
% buried
85
Peptide accession
Q9HCL2
Residue number A
623
Residue number B
643
Peptide name
Glycerol-3-phosphate acyltransferase 1, mitochondrial

Ligandability

Cysteine 623 of Glycerol-3-phosphate acyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 643 of Glycerol-3-phosphate acyltransferase 1, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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