ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Platelet glycoprotein VI

Intramolecular
Cysteine 48 and cysteine 88
Cysteine 134 and cysteine 180
A redox-regulated disulphide may form within Platelet glycoprotein VI between cysteines 48 and 88 (28 and 68 respectively in this structure).

Details

Redox score ?
84
PDB code
5ou7
Structure name
crystal structure of the glycoprotein vi loop truncation mutant pavs- papykn
Structure deposition date
2017-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCN6
Residue number A
48
Residue number B
88
Peptide name
Platelet glycoprotein VI

Ligandability

Cysteine 48 of Platelet glycoprotein VI

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of Platelet glycoprotein VI

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Platelet glycoprotein VI between cysteines 134 and 180 (110 and 150 respectively in this structure).

Details

Redox score ?
82
PDB code
5ou8
Structure name
crystal structure of glycoprotein vi in complex with collagen-peptide (gpo)5
Structure deposition date
2017-08-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9HCN6
Residue number A
134
Residue number B
180
Peptide name
Platelet glycoprotein VI

Ligandability

Cysteine 134 of Platelet glycoprotein VI

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Platelet glycoprotein VI

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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