ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Pre-mRNA-splicing factor SYF1

Intramolecular
Cysteine 668 and cysteine 691
Cysteine 691 and cysteine 695 L
Cysteine 668 and cysteine 695 L
A redox-regulated disulphide may form within Pre-mRNA-splicing factor SYF1 between cysteines 668 and 691.

Details

Redox score ?
74
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
8
% buried
64
Peptide accession
Q9HCS7
Residue number A
668
Residue number B
691
Peptide name
Pre-mRNA-splicing factor SYF1

Ligandability

Cysteine 668 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 691 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor SYF1 between cysteines 691 and 695.

Details

Redox score ?
72
PDB code
7w59
Structure name
the cryo-em structure of human pre-c*-i complex
Structure deposition date
2021-11-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
50
Peptide accession
Q9HCS7
Residue number A
691
Residue number B
695
Peptide name
Pre-mRNA-splicing factor SYF1

Ligandability

Cysteine 691 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 695 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Pre-mRNA-splicing factor SYF1 between cysteines 668 and 695. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7w5a
Structure name
the cryo-em structure of human pre-c*-ii complex
Structure deposition date
2021-11-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
54
Peptide accession
Q9HCS7
Residue number A
668
Residue number B
695
Peptide name
Pre-mRNA-splicing factor SYF1

Ligandability

Cysteine 668 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 695 of Pre-mRNA-splicing factor SYF1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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