ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bcl-2-like protein 10

Intramolecular
Cysteine 125 and cysteine 126
Cysteine 23 and cysteine 61
A redox-regulated disulphide may form within Bcl-2-like protein 10 between cysteines 125 and 126. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
2kua
Structure name
solution structure of a divergent bcl-2 protein
Structure deposition date
2010-02-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
31
Peptide accession
Q9Z0F3
Residue number A
125
Residue number B
126
Peptide name
Bcl-2-like protein 10

Ligandability

Cysteine 125 of Bcl-2-like protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 126 of Bcl-2-like protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bcl-2-like protein 10 between cysteines 23 and 61. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2kua
Structure name
solution structure of a divergent bcl-2 protein
Structure deposition date
2010-02-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
69
Peptide accession
Q9Z0F3
Residue number A
23
Residue number B
61
Peptide name
Bcl-2-like protein 10

Ligandability

Cysteine 23 of Bcl-2-like protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 61 of Bcl-2-like protein 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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