ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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O-phosphoseryl-tRNA(Sec) selenium transferase

Intramolecular
Cysteine 41 and cysteine 331
Cysteine 226 and cysteine 262
Cysteine 219 and cysteine 242
Cysteine 151 and cysteine 219
Cysteine 175 and cysteine 226
A redox-regulated disulphide may form within O-phosphoseryl-tRNA(Sec) selenium transferase between cysteines 41 and 331.

Details

Redox score ?
67
PDB code
3bca
Structure name
crystal structure of mouse selenocysteine synthase, sodium iodide soak
Structure deposition date
2007-11-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
58
Peptide accession
Q6P6M7
Residue number A
41
Residue number B
331
Peptide name
O-phosphoseryl-tRNA(Sec) selenium transferase

Ligandability

Cysteine 41 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 331 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within O-phosphoseryl-tRNA(Sec) selenium transferase between cysteines 226 and 262. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7mdl
Structure name
high-resolution crystal structure of human sepsecs-trnasec complex
Structure deposition date
2021-04-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
100
Peptide accession
Q9HD40
Residue number A
226
Residue number B
262
Peptide name
O-phosphoseryl-tRNA(Sec) selenium transferase

Ligandability

Cysteine 226 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 262 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within O-phosphoseryl-tRNA(Sec) selenium transferase between cysteines 219 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7mdl
Structure name
high-resolution crystal structure of human sepsecs-trnasec complex
Structure deposition date
2021-04-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
100
Peptide accession
Q9HD40
Residue number A
219
Residue number B
242
Peptide name
O-phosphoseryl-tRNA(Sec) selenium transferase

Ligandability

Cysteine 219 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within O-phosphoseryl-tRNA(Sec) selenium transferase between cysteines 151 and 219. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
3hl2
Structure name
the crystal structure of the human sepsecs-trnasec complex
Structure deposition date
2009-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
98
Minimum pKa ?
12
% buried
100
Peptide accession
Q9HD40
Residue number A
151
Residue number B
219
Peptide name
O-phosphoseryl-tRNA(Sec) selenium transferase

Ligandability

Cysteine 151 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within O-phosphoseryl-tRNA(Sec) selenium transferase between cysteines 175 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
3hl2
Structure name
the crystal structure of the human sepsecs-trnasec complex
Structure deposition date
2009-05-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
100
Peptide accession
Q9HD40
Residue number A
175
Residue number B
226
Peptide name
O-phosphoseryl-tRNA(Sec) selenium transferase

Ligandability

Cysteine 175 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of O-phosphoseryl-tRNA(Sec) selenium transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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