a tool for identifying drug-targetable redox-active disulphides

Receptor-type tyrosine-protein phosphatase H

Intramolecular

Cysteine 921 and cysteine 929

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase H between cysteines 921 and 929.

Details

Redox score ?

61

PDB code

Structure name

crystal structure of human rptph

Structure deposition date

2022-03-22

Thiol separation (Å)

5

Half-sphere exposure sum ?

65

Minimum pK_a ?

11

% buried

76

Peptide accession

Residue number A

921

Residue number B

929

Peptide name

Receptor-type tyrosine-protein phosphatase H

Ligandability

Cysteine 921 of Receptor-type tyrosine-protein phosphatase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 929 of Receptor-type tyrosine-protein phosphatase H

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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