ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

MHC class I recognition receptor Ly49I

Intermolecular
Cysteine 149 and cysteine 149
Cysteine 154 and cysteine 149
Cysteine 154 and cysteine 154
Intramolecular
Cysteine 236 and cysteine 249
Cysteine 171 and cysteine 257
Cysteine 167 and cysteine 255
Cysteine 167 and cysteine 171
Cysteine 171 and cysteine 255
Cysteine 167 and cysteine 257
Cysteine 255 and cysteine 257
Cysteine 167 and cysteine 236
A redox-regulated disulphide may form between two units of MHC class I recognition receptor Ly49I at cysteines 149 and 149 (145 and 145 respectively in this structure).

Details

Redox score ?
62
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide A name
MHC class I recognition receptor Ly49I
Peptide B name
MHC class I recognition receptor Ly49I
Peptide A accession
Q9JHN9
Peptide B accession
Q9JHN9
Peptide A residue number
149
Peptide B residue number
149

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MHC class I recognition receptor Ly49I at cysteines 154 and 149 (150 and 145 respectively in this structure).

Details

Redox score ?
61
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide A name
MHC class I recognition receptor Ly49I
Peptide B name
MHC class I recognition receptor Ly49I
Peptide A accession
Q9JHN9
Peptide B accession
Q9JHN9
Peptide A residue number
154
Peptide B residue number
149

Ligandability

Cysteine 154 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of MHC class I recognition receptor Ly49I at cysteines 154 and 154 (150 and 150 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide A name
MHC class I recognition receptor Ly49I
Peptide B name
MHC class I recognition receptor Ly49I
Peptide A accession
Q9JHN9
Peptide B accession
Q9JHN9
Peptide A residue number
154
Peptide B residue number
154

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 236 and 249 (232 and 245 respectively in this structure).

Details

Redox score ?
87
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
236
Residue number B
249
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 236 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 249 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 171 and 257 (167 and 253 respectively in this structure).

Details

Redox score ?
82
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
171
Residue number B
257
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 171 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 167 and 255 (163 and 251 respectively in this structure).

Details

Redox score ?
80
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
167
Residue number B
255
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 167 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 167 and 171 (163 and 167 respectively in this structure).

Details

Redox score ?
68
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
167
Residue number B
171
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 167 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 171 and 255 (167 and 251 respectively in this structure).

Details

Redox score ?
65
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
171
Residue number B
255
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 171 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 167 and 257 (163 and 253 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
167
Residue number B
257
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 167 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 255 and 257 (251 and 253 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
6
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
255
Residue number B
257
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 255 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I recognition receptor Ly49I between cysteines 167 and 236 (163 and 232 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1ja3
Structure name
crystal structure of the murine nk cell inhibitory receptor ly-49i
Structure deposition date
2001-05-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JHN9
Residue number A
167
Residue number B
236
Peptide name
MHC class I recognition receptor Ly49I

Ligandability

Cysteine 167 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 236 of MHC class I recognition receptor Ly49I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: