ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Anti-myosin immunoglobulin heavy chain variable region

Intramolecular
Cysteine 13 and cysteine 87
Cysteine 13 and cysteine 195
A redox-regulated disulphide may form within Anti-myosin immunoglobulin heavy chain variable region between cysteines 13 and 87 (22 and 96 respectively in this structure).

Details

Redox score ?
80
PDB code
2ddq
Structure name
crystal structure of the fab fragment of a r310 antibody complexed with (r)-hne-histidine adduct
Structure deposition date
2006-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JL75
Residue number A
13
Residue number B
87
Peptide name
Anti-myosin immunoglobulin heavy chain variable region

Ligandability

Cysteine 13 of Anti-myosin immunoglobulin heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 87 of Anti-myosin immunoglobulin heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-myosin immunoglobulin heavy chain variable region between cysteines 13 and 195 (140 and 195 respectively in this structure).

Details

Redox score ?
nan
PDB code
1p7k
Structure name
crystal structure of an anti-ssdna antigen-binding fragment (fab) bound to 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid (hepes)
Structure deposition date
2003-05-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JL75
Residue number A
13
Residue number B
195
Peptide name
Anti-myosin immunoglobulin heavy chain variable region

Ligandability

Cysteine 13 of Anti-myosin immunoglobulin heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of Anti-myosin immunoglobulin heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 in protein B could not be asigned to a Uniprot residue.
If this tool was useful for finding a disulphide, please cite: