ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Thioredoxin reductase 2, mitochondrial

Intramolecular
Cysteine 86 and cysteine 91
Cysteine 446 and cysteine 500
A redox-regulated disulphide may form within Thioredoxin reductase 2, mitochondrial between cysteines 86 and 91 (53 and 58 respectively in this structure).

Details

Redox score ?
79
PDB code
3dgz
Structure name
crystal structure of mouse mitochondrial thioredoxin reductase, c- terminal 3-residue truncation
Structure deposition date
2008-06-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9JLT4
Residue number A
86
Residue number B
91
Peptide name
Thioredoxin reductase 2, mitochondrial

Ligandability

Cysteine 86 of Thioredoxin reductase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Thioredoxin reductase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thioredoxin reductase 2, mitochondrial between cysteines 446 and 500 (413 and 467 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3dgz
Structure name
crystal structure of mouse mitochondrial thioredoxin reductase, c- terminal 3-residue truncation
Structure deposition date
2008-06-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
68
Peptide accession
Q9JLT4
Residue number A
446
Residue number B
500
Peptide name
Thioredoxin reductase 2, mitochondrial

Ligandability

Cysteine 446 of Thioredoxin reductase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 500 of Thioredoxin reductase 2, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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