RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Intramolecular
Cysteine 12 and cysteine 111
Cysteine 156 and cysteine 159
Cysteine 156 and cysteine 161
Cysteine 159 and cysteine 161
3o2s B 12 B 111
A redox-regulated disulphide may form within RNA polymerase II subunit A C-terminal domain phosphatase SSU72 between cysteines 12 and 111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
3o2s
Structure name
crystal structure of the human symplekin-ssu72 complex
Structure deposition date
2010-07-22
Thiol separation (Å)
5
Half-sphere exposure sum ?
101
Minimum pKa ?
8
% buried
100
Peptide accession
Q9NP77
Residue number A
12
Residue number B
111
Peptide name
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligandability
Cysteine 12 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Cysteine 111 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
4h3h B 156 B 159
A redox-regulated disulphide may form within RNA polymerase II subunit A C-terminal domain phosphatase SSU72 between cysteines 156 and 159. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
4h3h
Structure name
crystal structure of a ternary complex of human symplekin ntd, human ssu72 and a rna poymerase ii ctd peptide phosphorylated at ser-7
Structure deposition date
2012-09-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
60
Peptide accession
Q9NP77
Residue number A
156
Residue number B
159
Peptide name
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligandability
Cysteine 156 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Cysteine 159 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
4h3k B 156 B 161
A redox-regulated disulphide may form within RNA polymerase II subunit A C-terminal domain phosphatase SSU72 between cysteines 156 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
4h3k
Structure name
crystal structure of a ternary complex of human symplekin ntd, human ssu72 and a rna polymerase ii ctd peptide phosphorylated at ser-2, ser-5 and ser-7
Structure deposition date
2012-09-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
24
Peptide accession
Q9NP77
Residue number A
156
Residue number B
161
Peptide name
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligandability
Cysteine 156 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Cysteine 161 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
3o2s B 159 B 161
A redox-regulated disulphide may form within RNA polymerase II subunit A C-terminal domain phosphatase SSU72 between cysteines 159 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
3o2s
Structure name
crystal structure of the human symplekin-ssu72 complex
Structure deposition date
2010-07-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
58
Peptide accession
Q9NP77
Residue number A
159
Residue number B
161
Peptide name
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Ligandability
Cysteine 159 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Cysteine 161 of RNA polymerase II subunit A C-terminal domain phosphatase SSU72
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