ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Serine--tRNA ligase, mitochondrial

Intramolecular
Cysteine 64 and cysteine 66
Cysteine 324 and cysteine 328
Cysteine 272 and cysteine 425
A redox-regulated disulphide may form within Serine--tRNA ligase, mitochondrial between cysteines 64 and 66. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7tzb
Structure name
crystal structure of the human mitochondrial seryl-trna synthetase (mt serrs) bound with a seryl-adenylate analogue
Structure deposition date
2022-02-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide accession
Q9NP81
Residue number A
64
Residue number B
66
Peptide name
Serine--tRNA ligase, mitochondrial

Ligandability

Cysteine 64 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine--tRNA ligase, mitochondrial between cysteines 324 and 328. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7tzb
Structure name
crystal structure of the human mitochondrial seryl-trna synthetase (mt serrs) bound with a seryl-adenylate analogue
Structure deposition date
2022-02-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
100
Peptide accession
Q9NP81
Residue number A
324
Residue number B
328
Peptide name
Serine--tRNA ligase, mitochondrial

Ligandability

Cysteine 324 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 328 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Serine--tRNA ligase, mitochondrial between cysteines 272 and 425. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7tzb
Structure name
crystal structure of the human mitochondrial seryl-trna synthetase (mt serrs) bound with a seryl-adenylate analogue
Structure deposition date
2022-02-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
92
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NP81
Residue number A
272
Residue number B
425
Peptide name
Serine--tRNA ligase, mitochondrial

Ligandability

Cysteine 272 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 425 of Serine--tRNA ligase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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