ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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39S ribosomal protein S30, mitochondrial

Intermolecular
Cysteine 153 of 39S ribosomal protein L37, mitochondrial and cysteine 292 L
Cysteine 203 of 39S ribosomal protein L37, mitochondrial and cysteine 149 L
Intramolecular
Cysteine 292 and cysteine 293 L
Cysteine 147 and cysteine 149
Cysteine 371 and cysteine 393
A redox-regulated disulphide may form between cysteine 153 of 39S ribosomal protein L37, mitochondrial and cysteine 292 of 39S ribosomal protein S30, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7oib
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3d
Structure deposition date
2021-05-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
64
Peptide A name
39S ribosomal protein L37, mitochondrial
Peptide B name
39S ribosomal protein S30, mitochondrial
Peptide A accession
Q9BZE1
Peptide B accession
Q9NP92
Peptide A residue number
153
Peptide B residue number
292

Ligandability

Cysteine 153 of 39S ribosomal protein L37, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 203 of 39S ribosomal protein L37, mitochondrial and cysteine 149 of 39S ribosomal protein S30, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7of0
Structure name
structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with mterf4-nsun4 (dataset1)
Structure deposition date
2021-05-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
10
% buried
100
Peptide A name
39S ribosomal protein L37, mitochondrial
Peptide B name
39S ribosomal protein S30, mitochondrial
Peptide A accession
Q9BZE1
Peptide B accession
Q9NP92
Peptide A residue number
203
Peptide B residue number
149

Ligandability

Cysteine 203 of 39S ribosomal protein L37, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 149 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein S30, mitochondrial between cysteines 292 and 293. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
7qh6
Structure name
cryo-em structure of the human mtlsu assembly intermediate upon mrm2 depletion - class 1
Structure deposition date
2021-12-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
72
Peptide accession
Q9NP92
Residue number A
292
Residue number B
293
Peptide name
39S ribosomal protein S30, mitochondrial

Ligandability

Cysteine 292 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 293 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein S30, mitochondrial between cysteines 147 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7oia
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3c
Structure deposition date
2021-05-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
74
Peptide accession
Q9NP92
Residue number A
147
Residue number B
149
Peptide name
39S ribosomal protein S30, mitochondrial

Ligandability

Cysteine 147 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 39S ribosomal protein S30, mitochondrial between cysteines 371 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
7oia
Structure name
cryo-em structure of late human 39s mitoribosome assembly intermediates, state 3c
Structure deposition date
2021-05-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NP92
Residue number A
371
Residue number B
393
Peptide name
39S ribosomal protein S30, mitochondrial

Ligandability

Cysteine 371 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of 39S ribosomal protein S30, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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