a tool for identifying drug-targetable redox-active disulphides

Exosome complex component RRP41

Intramolecular

Cysteine 158 and cysteine 160

A redox-regulated disulphide may form within Exosome complex component RRP41 between cysteines 158 and 160 (157 and 159 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

34

PDB code

Structure name

structure of the human rna exosome composed of rrp41, rrp45, rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40

Structure deposition date

2006-10-23

Thiol separation (Å)

7

Half-sphere exposure sum ?

96

Minimum pK_a ?

13

% buried

100

Peptide accession

Residue number A

158

Residue number B

160

Peptide name

Exosome complex component RRP41

Ligandability

Cysteine 158 of Exosome complex component RRP41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 160 of Exosome complex component RRP41

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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