a tool for identifying drug-targetable redox-active disulphides

tRNA N6-adenosine threonylcarbamoyltransferase

Intramolecular

Cysteine 265 and cysteine 292 L

A redox-regulated disulphide may form within tRNA N6-adenosine threonylcarbamoyltransferase between cysteines 265 and 292.

Details

Redox score ?

78

PDB code

Structure name

human osgep / lage3 / gon7 complex

Structure deposition date

2018-06-25

Thiol separation (Å)

3

Half-sphere exposure sum ?

68

Minimum pK_a ?

7

% buried

70

Peptide accession

Residue number A

265

Residue number B

292

Peptide name

tRNA N6-adenosine threonylcarbamoyltransferase

Ligandability

Cysteine 265 of tRNA N6-adenosine threonylcarbamoyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 292 of tRNA N6-adenosine threonylcarbamoyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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