ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neuroglobin

Intramolecular
Cysteine 46 and cysteine 55
Cysteine 15 and cysteine 120
A redox-regulated disulphide may form within Neuroglobin between cysteines 46 and 55.

Details

Redox score ?
89
PDB code
4mpm
Structure name
wild-type human neuroglobin
Structure deposition date
2013-09-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
45
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NPG2
Residue number A
46
Residue number B
55
Peptide name
Neuroglobin

Ligandability

Cysteine 46 of Neuroglobin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 55 of Neuroglobin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neuroglobin between cysteines 15 and 120.

Details

Redox score ?
nan
PDB code
7vqg
Structure name
the x-ray structure of human neuroglobin a15c mutant
Structure deposition date
2021-10-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NPG2
Residue number A
15
Residue number B
120
Peptide name
Neuroglobin

Ligandability

Cysteine 15 of Neuroglobin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Neuroglobin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 15 in protein A could not be asigned to a Uniprot residue.
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