ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysophosphatidic acid phosphatase type 6

Intramolecular
Cysteine 388 and cysteine 393
Cysteine 208 and cysteine 416
Cysteine 175 and cysteine 183
A redox-regulated disulphide may form within Lysophosphatidic acid phosphatase type 6 between cysteines 388 and 393.

Details

Redox score ?
88
PDB code
4job
Structure name
crystal structure of human lysophosphatidic acid phosphatase type 6 complexed with l-(+)-tartrate
Structure deposition date
2013-03-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NPH0
Residue number A
388
Residue number B
393
Peptide name
Lysophosphatidic acid phosphatase type 6

Ligandability

Cysteine 388 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 393 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid phosphatase type 6 between cysteines 208 and 416.

Details

Redox score ?
77
PDB code
4jod
Structure name
crystal structure of human lysophosphatidic acid phosphatase type 6 complexed with tris
Structure deposition date
2013-03-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
46
Peptide accession
Q9NPH0
Residue number A
208
Residue number B
416
Peptide name
Lysophosphatidic acid phosphatase type 6

Ligandability

Cysteine 208 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysophosphatidic acid phosphatase type 6 between cysteines 175 and 183. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4joc
Structure name
crystal structure of human lysophosphatidic acid phosphatase type 6 complexed with malonate
Structure deposition date
2013-03-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
59
Peptide accession
Q9NPH0
Residue number A
175
Residue number B
183
Peptide name
Lysophosphatidic acid phosphatase type 6

Ligandability

Cysteine 175 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Lysophosphatidic acid phosphatase type 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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