a tool for identifying drug-targetable redox-active disulphides

Mediator of RNA polymerase II transcription subunit 4

Intermolecular

Cysteine 162 and cysteine 598 of Mediator of RNA polymerase II transcription subunit 26

A redox-regulated disulphide may form between cysteine 162 of Mediator of RNA polymerase II transcription subunit 4 and cysteine 598 of Mediator of RNA polymerase II transcription subunit 26. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

31

PDB code

Structure name

human mediator (deletion of med1-idr) in a tail-bent conformation (med-b)

Structure deposition date

2021-04-17

Thiol separation (Å)

10

Half-sphere exposure sum ?

75

Minimum pK_a ?

10

% buried

90

Peptide A name

Mediator of RNA polymerase II transcription subunit 4

Peptide B name

Mediator of RNA polymerase II transcription subunit 26

Peptide A accession

Peptide B accession

Peptide A residue number

162

Peptide B residue number

598

Ligandability

Cysteine 162 of Mediator of RNA polymerase II transcription subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 598 of Mediator of RNA polymerase II transcription subunit 26

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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