ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Synembryn-A

Intermolecular
Cysteine 122 and cysteine 351 of Guanine nucleotide-binding protein G(t) subunit alpha-2
Intramolecular
Cysteine 120 and cysteine 122
A redox-regulated disulphide may form between cysteine 122 of Synembryn-A and cysteine 351 of Guanine nucleotide-binding protein G(t) subunit alpha-2 (122 and 392 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
6n85
Structure name
resistance to inhibitors of cholinesterase 8a (ric8a) protein in complex with mbp-tagged transducin-alpha residues 327-350
Structure deposition date
2018-11-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
86
Peptide A name
Synembryn-A
Peptide B name
Guanine nucleotide-binding protein G(t) subunit alpha-2
Peptide A accession
Q5E9J8
Peptide B accession
P19087
Peptide A residue number
122
Peptide B residue number
351

Ligandability

Cysteine 122 of Synembryn-A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 351 of Guanine nucleotide-binding protein G(t) subunit alpha-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Synembryn-A between cysteines 120 and 122. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
6n86
Structure name
resistance to inhibitors of cholinesterase 8a (ric8a) protein
Structure deposition date
2018-11-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
100
Peptide accession
Q5E9J8
Residue number A
120
Residue number B
122
Peptide name
Synembryn-A

Ligandability

Cysteine 120 of Synembryn-A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Synembryn-A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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