ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fructose-2,6-bisphosphatase TIGAR

Intramolecular
Cysteine 215 and cysteine 254 L
Cysteine 254 and cysteine 256 L
A redox-regulated disulphide may form within Fructose-2,6-bisphosphatase TIGAR between cysteines 215 and 254.

Details

Redox score ?
64
PDB code
3dcy
Structure name
crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens
Structure deposition date
2008-06-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
66
Peptide accession
Q9NQ88
Residue number A
215
Residue number B
254
Peptide name
Fructose-2,6-bisphosphatase TIGAR

Ligandability

Cysteine 215 of Fructose-2,6-bisphosphatase TIGAR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of Fructose-2,6-bisphosphatase TIGAR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fructose-2,6-bisphosphatase TIGAR between cysteines 254 and 256. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
3dcy
Structure name
crystal structure a tp53-induced glycolysis and apoptosis regulator protein from homo sapiens
Structure deposition date
2008-06-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
nan
Minimum pKa ?
12
% buried
77
Peptide accession
Q9NQ88
Residue number A
254
Residue number B
256
Peptide name
Fructose-2,6-bisphosphatase TIGAR

Ligandability

Cysteine 254 of Fructose-2,6-bisphosphatase TIGAR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 256 of Fructose-2,6-bisphosphatase TIGAR

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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