ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily V member 5

Intramolecular
Cysteine 342 and cysteine 346
Cysteine 346 and cysteine 347
Cysteine 342 and cysteine 347
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 5 between cysteines 342 and 346.

Details

Redox score ?
69
PDB code
7t6r
Structure name
cryo-em structure of trpv5 t709d in nanodiscs in the presence of calmodulin
Structure deposition date
2021-12-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
46
Peptide accession
Q9XSM3
Residue number A
342
Residue number B
346
Peptide name
Transient receptor potential cation channel subfamily V member 5

Ligandability

Cysteine 342 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 346 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 5 between cysteines 346 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
46
PDB code
6o1u
Structure name
cryo-em structure of trpv5 w583a in nanodisc
Structure deposition date
2019-02-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
81
Peptide accession
Q9XSM3
Residue number A
346
Residue number B
347
Peptide name
Transient receptor potential cation channel subfamily V member 5

Ligandability

Cysteine 346 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 5 between cysteines 342 and 347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7t6n
Structure name
cryo-em structure of trpv5 in nanodiscs at ph6 state 2
Structure deposition date
2021-12-14
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
68
Peptide accession
Q9XSM3
Residue number A
342
Residue number B
347
Peptide name
Transient receptor potential cation channel subfamily V member 5

Ligandability

Cysteine 342 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 347 of Transient receptor potential cation channel subfamily V member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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