ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-lysine methyltransferase KMT5A

Intermolecular
Cysteine 311 and cysteine 311
Intramolecular
Cysteine 311 and cysteine 324 L
A redox-regulated disulphide may form between two units of N-lysine methyltransferase KMT5A at cysteines 311 and 311.

Details

Redox score ?
73
PDB code
5w1y
Structure name
setd8 in complex with a covalent inhibitor
Structure deposition date
2017-06-05
Thiol separation (Å)
3
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
N-lysine methyltransferase KMT5A
Peptide B name
N-lysine methyltransferase KMT5A
Peptide A accession
Q9NQR1
Peptide B accession
Q9NQR1
Peptide A residue number
311
Peptide B residue number
311

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-lysine methyltransferase KMT5A between cysteines 311 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5th7
Structure name
complex of setd8 with ms453
Structure deposition date
2016-09-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NQR1
Residue number A
311
Residue number B
324
Peptide name
N-lysine methyltransferase KMT5A

Ligandability

Cysteine 311 of N-lysine methyltransferase KMT5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of N-lysine methyltransferase KMT5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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