Exosome complex component RRP40

Intermolecular

Cysteine 138 of Exosome complex component RRP46 and cysteine 83

Intramolecular

A redox-regulated disulphide may form between cysteine 138 of Exosome complex component RRP46 and cysteine 83 of Exosome complex component RRP40. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6d6r

Structure name

human nuclear exosome-mtr4 rna complex - composite map after focused reconstruction

Structure deposition date

2018-04-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Exosome complex component RRP46

Peptide B name

Exosome complex component RRP40

Peptide A accession

Q9NQT4

Peptide B accession

Q9NQT5

Peptide A residue number

138

Peptide B residue number

Ligandability

Cysteine 138 of Exosome complex component RRP46

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 83 of Exosome complex component RRP40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP40 between cysteines 67 and 74. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6h25

Structure name

human nuclear rna exosome exo-10-mpp6 complex

Structure deposition date

2018-07-13

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q9NQT5

Residue number A

Residue number B

Peptide name

Exosome complex component RRP40

Ligandability

Cysteine 67 of Exosome complex component RRP40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of Exosome complex component RRP40

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exosome complex component RRP40 between cysteines 215 and 257 (214 and 256 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?