a tool for identifying drug-targetable redox-active disulphides

Anillin

Intramolecular

Cysteine 743 and cysteine 744

A redox-regulated disulphide may form within Anillin between cysteines 743 and 744 (32 and 33 respectively in this structure).

Details

Redox score ?

62

PDB code

Structure name

mechanistic insights into anchorage of the contractile ring from yeast to humans

Structure deposition date

2015-01-04

Thiol separation (Å)

7

Half-sphere exposure sum ?

41

Minimum pK_a ?

9

% buried

5

Peptide accession

Residue number A

743

Residue number B

744

Peptide name

Anillin

Ligandability

Cysteine 743 of Anillin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 744 of Anillin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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