ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Xaa-Pro aminopeptidase 1

Intramolecular
Cysteine 308 and cysteine 309
Cysteine 46 and cysteine 48
Cysteine 342 and cysteine 592
Cysteine 316 and cysteine 502
A redox-regulated disulphide may form within Xaa-Pro aminopeptidase 1 between cysteines 308 and 309. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
3ctz
Structure name
structure of human cytosolic x-prolyl aminopeptidase
Structure deposition date
2008-04-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
38
Peptide accession
Q9NQW7
Residue number A
308
Residue number B
309
Peptide name
Xaa-Pro aminopeptidase 1

Ligandability

Cysteine 308 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xaa-Pro aminopeptidase 1 between cysteines 46 and 48. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3ctz
Structure name
structure of human cytosolic x-prolyl aminopeptidase
Structure deposition date
2008-04-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
55
Peptide accession
Q9NQW7
Residue number A
46
Residue number B
48
Peptide name
Xaa-Pro aminopeptidase 1

Ligandability

Cysteine 46 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 48 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xaa-Pro aminopeptidase 1 between cysteines 342 and 592. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3ctz
Structure name
structure of human cytosolic x-prolyl aminopeptidase
Structure deposition date
2008-04-15
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
100
Peptide accession
Q9NQW7
Residue number A
342
Residue number B
592
Peptide name
Xaa-Pro aminopeptidase 1

Ligandability

Cysteine 342 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 592 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Xaa-Pro aminopeptidase 1 between cysteines 316 and 502. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3ctz
Structure name
structure of human cytosolic x-prolyl aminopeptidase
Structure deposition date
2008-04-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
90
Peptide accession
Q9NQW7
Residue number A
316
Residue number B
502
Peptide name
Xaa-Pro aminopeptidase 1

Ligandability

Cysteine 316 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 502 of Xaa-Pro aminopeptidase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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