ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein arginine N-methyltransferase 8

Intermolecular
Cysteine 295 and cysteine 295
Intramolecular
Cysteine 273 and cysteine 295
A redox-regulated disulphide may form between two units of Protein arginine N-methyltransferase 8 at cysteines 295 and 295.

Details

Redox score ?
63
PDB code
5dst
Structure name
crystal structure of human prmt8 in complex with sah
Structure deposition date
2015-09-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
96
Peptide A name
Protein arginine N-methyltransferase 8
Peptide B name
Protein arginine N-methyltransferase 8
Peptide A accession
Q9NR22
Peptide B accession
Q9NR22
Peptide A residue number
295
Peptide B residue number
295

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein arginine N-methyltransferase 8 between cysteines 273 and 295.

Details

Redox score ?
61
PDB code
4x41
Structure name
crystal structure of protein arginine methyltransferase prmt8
Structure deposition date
2014-12-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
11
Peptide accession
Q9NR22
Residue number A
273
Residue number B
295
Peptide name
Protein arginine N-methyltransferase 8

Ligandability

Cysteine 273 of Protein arginine N-methyltransferase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 295 of Protein arginine N-methyltransferase 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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