ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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GTP-binding protein SAR1a

Intramolecular
Cysteine 102 and cysteine 178 L
A redox-regulated disulphide may form within GTP-binding protein SAR1a between cysteines 102 and 178. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
8e0h
Structure name
crystal structure of human sar1ad104/d140a double mutant
Structure deposition date
2022-08-09
Thiol separation (Å)
8
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
90
Peptide accession
Q9NR31
Residue number A
102
Residue number B
178
Peptide name
GTP-binding protein SAR1a

Ligandability

Cysteine 102 of GTP-binding protein SAR1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of GTP-binding protein SAR1a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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