ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Translation initiation factor eIF-2B subunit gamma

Intramolecular
Cysteine 64 and cysteine 77 L
Cysteine 281 and cysteine 285 L
Cysteine 77 and cysteine 106
A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit gamma between cysteines 64 and 77.

Details

Redox score ?
79
PDB code
7d45
Structure name
eif2b-eif2(ap), ap1 complex
Structure deposition date
2020-09-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
22
Peptide accession
Q9NR50
Residue number A
64
Residue number B
77
Peptide name
Translation initiation factor eIF-2B subunit gamma

Ligandability

Cysteine 64 of Translation initiation factor eIF-2B subunit gamma

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 77 of Translation initiation factor eIF-2B subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit gamma between cysteines 281 and 285. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7d44
Structure name
eif2b-eif2(ap), ap2 complex
Structure deposition date
2020-09-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
50
Peptide accession
Q9NR50
Residue number A
281
Residue number B
285
Peptide name
Translation initiation factor eIF-2B subunit gamma

Ligandability

Cysteine 281 of Translation initiation factor eIF-2B subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 285 of Translation initiation factor eIF-2B subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Translation initiation factor eIF-2B subunit gamma between cysteines 77 and 106. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6o9z
Structure name
electron cryo-microscopy of the eukaryotic translation initiation factor 2b bound to eukaryotic translation initiation factor 2 from homo sapiens
Structure deposition date
2019-03-15
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
49
Peptide accession
Q9NR50
Residue number A
77
Residue number B
106
Peptide name
Translation initiation factor eIF-2B subunit gamma

Ligandability

Cysteine 77 of Translation initiation factor eIF-2B subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Translation initiation factor eIF-2B subunit gamma

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: