ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rho guanine nucleotide exchange factor 4

Intramolecular
Cysteine 314 and cysteine 405
Cysteine 379 and cysteine 428
A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 4 between cysteines 314 and 405.

Details

Redox score ?
62
PDB code
2pz1
Structure name
crystal structure of auto-inhibited asef
Structure deposition date
2007-05-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
53
Minimum pKa ?
11
% buried
65
Peptide accession
Q9NR80
Residue number A
314
Residue number B
405
Peptide name
Rho guanine nucleotide exchange factor 4

Ligandability

Cysteine 314 of Rho guanine nucleotide exchange factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 405 of Rho guanine nucleotide exchange factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 4 between cysteines 379 and 428. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
2pz1
Structure name
crystal structure of auto-inhibited asef
Structure deposition date
2007-05-17
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
94
Peptide accession
Q9NR80
Residue number A
379
Residue number B
428
Peptide name
Rho guanine nucleotide exchange factor 4

Ligandability

Cysteine 379 of Rho guanine nucleotide exchange factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 428 of Rho guanine nucleotide exchange factor 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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