ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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SLC2A4 regulator

Intramolecular
Cysteine 373 and cysteine 382
Cysteine 373 and cysteine 376
Cysteine 360 and cysteine 373
Cysteine 360 and cysteine 382
Cysteine 376 and cysteine 382
Cysteine 360 and cysteine 376
A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 373 and 382.

Details

Redox score ?
85
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
6
% buried
24
Peptide accession
Q9NR83
Residue number A
373
Residue number B
382
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 373 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 373 and 376.

Details

Redox score ?
83
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
6
% buried
41
Peptide accession
Q9NR83
Residue number A
373
Residue number B
376
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 373 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 360 and 373.

Details

Redox score ?
81
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
25
Peptide accession
Q9NR83
Residue number A
360
Residue number B
373
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 360 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 360 and 382.

Details

Redox score ?
80
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
17
Peptide accession
Q9NR83
Residue number A
360
Residue number B
382
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 360 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 376 and 382.

Details

Redox score ?
79
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
33
Peptide accession
Q9NR83
Residue number A
376
Residue number B
382
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 376 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within SLC2A4 regulator between cysteines 360 and 376.

Details

Redox score ?
78
PDB code
7dta
Structure name
solution structure of the c-clamp domain from human hdbp1 in complex with dna
Structure deposition date
2021-01-04
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
34
Peptide accession
Q9NR83
Residue number A
360
Residue number B
376
Peptide name
SLC2A4 regulator

Ligandability

Cysteine 360 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of SLC2A4 regulator

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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