a tool for identifying drug-targetable redox-active disulphides

SH2B adapter protein 1

Intramolecular

Cysteine 564 and cysteine 587

A redox-regulated disulphide may form within SH2B adapter protein 1 between cysteines 564 and 587.

Details

Redox score ?

nan

PDB code

Structure name

crystal structure of the src homology-2 domain of the adapter protein sh2-b

Structure deposition date

2006-06-20

Thiol separation (Å)

8

Half-sphere exposure sum ?

66

Minimum pK_a ?

11

% buried

59

Peptide accession

Residue number A

564

Residue number B

587

Peptide name

SH2B adapter protein 1

Ligandability

Cysteine 564 of SH2B adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 587 of SH2B adapter protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 564 in protein A could not be asigned to a Uniprot residue.

If this tool was useful for finding a disulphide, please cite: