ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CTP synthase 2

Intramolecular
Cysteine 216 and cysteine 243 L
Cysteine 216 and cysteine 234 L
A redox-regulated disulphide may form within CTP synthase 2 between cysteines 216 and 243.

Details

Redox score ?
62
PDB code
3ihl
Structure name
human ctps2 crystal structure
Structure deposition date
2009-07-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
91
Minimum pKa ?
7
% buried
91
Peptide accession
Q9NRF8
Residue number A
216
Residue number B
243
Peptide name
CTP synthase 2

Ligandability

Cysteine 216 of CTP synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 243 of CTP synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CTP synthase 2 between cysteines 216 and 234. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7miu
Structure name
mouse ctps2 bound to inhibitor r80
Structure deposition date
2021-04-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
P70303
Residue number A
216
Residue number B
234
Peptide name
CTP synthase 2

Ligandability

Cysteine 216 of CTP synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 234 of CTP synthase 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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