ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

C-C motif chemokine 28

Intramolecular
Cysteine 30 and cysteine 58
Cysteine 31 and cysteine 73
Cysteine 49 and cysteine 99
Cysteine 30 and cysteine 31
Cysteine 31 and cysteine 58
Cysteine 58 and cysteine 73
Cysteine 30 and cysteine 73
Cysteine 31 and cysteine 49
Cysteine 49 and cysteine 73
Cysteine 31 and cysteine 99
A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 30 and 58 (11 and 39 respectively in this structure).

Details

Redox score ?
85
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
30
Residue number B
58
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 30 of C-C motif chemokine 28

Cysteine 58 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 31 and 73 (12 and 54 respectively in this structure).

Details

Redox score ?
82
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
31
Residue number B
73
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 31 of C-C motif chemokine 28

Cysteine 73 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 49 and 99 (30 and 80 respectively in this structure).

Details

Redox score ?
82
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
49
Residue number B
99
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 49 of C-C motif chemokine 28

Cysteine 99 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 30 and 31 (11 and 12 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
30
Residue number B
31
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 30 of C-C motif chemokine 28

Cysteine 31 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 31 and 58 (12 and 39 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
31
Residue number B
58
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 31 of C-C motif chemokine 28

Cysteine 58 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 58 and 73 (39 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
58
Residue number B
73
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 58 of C-C motif chemokine 28

Cysteine 73 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 30 and 73 (11 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
30
Residue number B
73
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 30 of C-C motif chemokine 28

Cysteine 73 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 31 and 49 (12 and 30 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
31
Residue number B
49
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 31 of C-C motif chemokine 28

Cysteine 49 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 49 and 73 (30 and 54 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
49
Residue number B
73
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 49 of C-C motif chemokine 28

Cysteine 73 of C-C motif chemokine 28

A redox-regulated disulphide may form within C-C motif chemokine 28 between cysteines 31 and 99 (12 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6cws
Structure name
the nmr solution structure of ccl28
Structure deposition date
2018-03-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRJ3
Residue number A
31
Residue number B
99
Peptide name
C-C motif chemokine 28

Ligandability

Cysteine 31 of C-C motif chemokine 28

Cysteine 99 of C-C motif chemokine 28

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