ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interleukin-17 receptor B

Intramolecular
Cysteine 24 and cysteine 102
Cysteine 257 and cysteine 261
Cysteine 162 and cysteine 173
Cysteine 187 and cysteine 271
Cysteine 87 and cysteine 99
Cysteine 428 and cysteine 460
Cysteine 173 and cysteine 257
Cysteine 99 and cysteine 102
Cysteine 87 and cysteine 102
A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 24 and 102.

Details

Redox score ?
87
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
24
Residue number B
102
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 24 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 257 and 261.

Details

Redox score ?
86
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
257
Residue number B
261
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 257 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 162 and 173.

Details

Redox score ?
85
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
162
Residue number B
173
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 162 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 187 and 271.

Details

Redox score ?
84
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
187
Residue number B
271
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 187 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 271 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 87 and 99.

Details

Redox score ?
82
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
87
Residue number B
99
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 87 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 428 and 460. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3vbc
Structure name
crystal structure of il-17 receptor b sefir domain
Structure deposition date
2012-01-02
Thiol separation (Å)
10
Half-sphere exposure sum ?
53
Minimum pKa ?
9
% buried
30
Peptide accession
Q9JIP3
Residue number A
428
Residue number B
460
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 428 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 460 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 173 and 257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7uwl
Structure name
structure of the il-25-il-17rb-il-17ra ternary complex
Structure deposition date
2022-05-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
173
Residue number B
257
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 173 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 99 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
99
Residue number B
102
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 99 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interleukin-17 receptor B between cysteines 87 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7uwk
Structure name
structure of the higher-order il-25-il-17rb complex
Structure deposition date
2022-05-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRM6
Residue number A
87
Residue number B
102
Peptide name
Interleukin-17 receptor B

Ligandability

Cysteine 87 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Interleukin-17 receptor B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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