ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Intramolecular
Cysteine 294 and cysteine 296
A redox-regulated disulphide may form within L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase between cysteines 294 and 296 (304 and 306 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2c43
Structure name
structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with coenzyme a
Structure deposition date
2005-10-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
37
Minimum pKa ?
10
% buried
10
Peptide accession
Q9P0Q3
Residue number A
294
Residue number B
296
Peptide name
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Ligandability

Cysteine 294 of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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