rRNA N6-adenosine-methyltransferase METTL5
Intramolecular
Cysteine 107 and cysteine 110
Cysteine 60 and cysteine 77
Cysteine 60 and cysteine 107
Cysteine 60 and cysteine 62
6h2v C 107 C 110
A redox-regulated disulphide may form within rRNA N6-adenosine-methyltransferase METTL5 between cysteines 107 and 110. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
6h2v
Structure name
crystal structure of human mettl5-trmt112 complex, the 18s rrna m6a1832 methyltransferase at 2
Structure deposition date
2018-07-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
56
Minimum pKa ?
11
% buried
68
Peptide accession
Q9NRN9
Residue number A
107
Residue number B
110
Peptide name
rRNA N6-adenosine-methyltransferase METTL5
Ligandability
Cysteine 107 of rRNA N6-adenosine-methyltransferase METTL5
Cysteine 110 of rRNA N6-adenosine-methyltransferase METTL5
6h2u A 60 A 77
A redox-regulated disulphide may form within rRNA N6-adenosine-methyltransferase METTL5 between cysteines 60 and 77. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6h2u
Structure name
crystal structure of human mettl5-trmt112 complex, the 18s rrna m6a1832 methyltransferase at 1
Structure deposition date
2018-07-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
98
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NRN9
Residue number A
60
Residue number B
77
Peptide name
rRNA N6-adenosine-methyltransferase METTL5
Ligandability
Cysteine 60 of rRNA N6-adenosine-methyltransferase METTL5
Cysteine 77 of rRNA N6-adenosine-methyltransferase METTL5
6h2v C 60 C 107
A redox-regulated disulphide may form within rRNA N6-adenosine-methyltransferase METTL5 between cysteines 60 and 107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6h2v
Structure name
crystal structure of human mettl5-trmt112 complex, the 18s rrna m6a1832 methyltransferase at 2
Structure deposition date
2018-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
100
Peptide accession
Q9NRN9
Residue number A
60
Residue number B
107
Peptide name
rRNA N6-adenosine-methyltransferase METTL5
Ligandability
Cysteine 60 of rRNA N6-adenosine-methyltransferase METTL5
Cysteine 107 of rRNA N6-adenosine-methyltransferase METTL5
6h2u A 60 A 62
A redox-regulated disulphide may form within rRNA N6-adenosine-methyltransferase METTL5 between cysteines 60 and 62. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
24
PDB code
6h2u
Structure name
crystal structure of human mettl5-trmt112 complex, the 18s rrna m6a1832 methyltransferase at 1
Structure deposition date
2018-07-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
96
Minimum pKa ?
14
% buried
100
Peptide accession
Q9NRN9
Residue number A
60
Residue number B
62
Peptide name
rRNA N6-adenosine-methyltransferase METTL5
Ligandability
Cysteine 60 of rRNA N6-adenosine-methyltransferase METTL5
Cysteine 62 of rRNA N6-adenosine-methyltransferase METTL5
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