ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease 3

Intramolecular
Cysteine 536 and cysteine 538
Cysteine 561 and cysteine 676
Cysteine 538 and cysteine 1031
Cysteine 857 and cysteine 920
Cysteine 675 and cysteine 676
Cysteine 1268 and cysteine 1269
Cysteine 536 and cysteine 1031
Cysteine 561 and cysteine 641
Cysteine 561 and cysteine 675
Cysteine 618 and cysteine 891
Cysteine 709 and cysteine 737
A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 536 and 538.

Details

Redox score ?
78
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
24
Peptide accession
Q9NRR4
Residue number A
536
Residue number B
538
Peptide name
Ribonuclease 3

Ligandability

Cysteine 536 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 538 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 561 and 676.

Details

Redox score ?
76
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
45
Peptide accession
Q9NRR4
Residue number A
561
Residue number B
676
Peptide name
Ribonuclease 3

Ligandability

Cysteine 561 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 676 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 538 and 1031.

Details

Redox score ?
76
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
26
Peptide accession
Q9NRR4
Residue number A
538
Residue number B
1031
Peptide name
Ribonuclease 3

Ligandability

Cysteine 538 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 857 and 920.

Details

Redox score ?
65
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
92
Peptide accession
Q9NRR4
Residue number A
857
Residue number B
920
Peptide name
Ribonuclease 3

Ligandability

Cysteine 857 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 920 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 675 and 676. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
21
Peptide accession
Q9NRR4
Residue number A
675
Residue number B
676
Peptide name
Ribonuclease 3

Ligandability

Cysteine 675 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 676 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 1268 and 1269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
67
Peptide accession
Q9NRR4
Residue number A
1268
Residue number B
1269
Peptide name
Ribonuclease 3

Ligandability

Cysteine 1268 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1269 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 536 and 1031. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
5b16
Structure name
x-ray structure of drosha in complex with the c-terminal tail of dgcr8
Structure deposition date
2015-11-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
47
Minimum pKa ?
8
% buried
21
Peptide accession
Q9NRR4
Residue number A
536
Residue number B
1031
Peptide name
Ribonuclease 3

Ligandability

Cysteine 536 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1031 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 561 and 641. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6lxd
Structure name
pri-mirna bound drosha-dgcr8 complex
Structure deposition date
2020-02-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
68
Peptide accession
Q9NRR4
Residue number A
561
Residue number B
641
Peptide name
Ribonuclease 3

Ligandability

Cysteine 561 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 641 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 561 and 675. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6v5c
Structure name
human drosha and dgcr8 in complex with primary microrna (mp/rna complex) - partially docked state
Structure deposition date
2019-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
48
Peptide accession
Q9NRR4
Residue number A
561
Residue number B
675
Peptide name
Ribonuclease 3

Ligandability

Cysteine 561 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 675 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 618 and 891. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6v5b
Structure name
human drosha and dgcr8 in complex with primary microrna (mp/rna complex) - active state
Structure deposition date
2019-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
66
Peptide accession
Q9NRR4
Residue number A
618
Residue number B
891
Peptide name
Ribonuclease 3

Ligandability

Cysteine 618 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 891 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease 3 between cysteines 709 and 737. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6lxe
Structure name
drosha-dgcr8 complex
Structure deposition date
2020-02-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
44
Peptide accession
Q9NRR4
Residue number A
709
Residue number B
737
Peptide name
Ribonuclease 3

Ligandability

Cysteine 709 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 737 of Ribonuclease 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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