ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity protein phosphatase 22

Intramolecular
Cysteine 77 and cysteine 84
Cysteine 88 and cysteine 124 L
A redox-regulated disulphide may form within Dual specificity protein phosphatase 22 between cysteines 77 and 84.

Details

Redox score ?
67
PDB code
6l1s
Structure name
crystal structure of dusp22 mutant_c88s
Structure deposition date
2019-09-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
8
% buried
74
Peptide accession
Q9NRW4
Residue number A
77
Residue number B
84
Peptide name
Dual specificity protein phosphatase 22

Ligandability

Cysteine 77 of Dual specificity protein phosphatase 22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of Dual specificity protein phosphatase 22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual specificity protein phosphatase 22 between cysteines 88 and 124. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6lvq
Structure name
crystal structure of dusp22_vo4
Structure deposition date
2020-02-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NRW4
Residue number A
88
Residue number B
124
Peptide name
Dual specificity protein phosphatase 22

Ligandability

Cysteine 88 of Dual specificity protein phosphatase 22

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 124 of Dual specificity protein phosphatase 22

Ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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