ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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14 kDa phosphohistidine phosphatase

Intramolecular
Cysteine 69 and cysteine 71 L
Cysteine 71 and cysteine 73 L
A redox-regulated disulphide may form within 14 kDa phosphohistidine phosphatase between cysteines 69 and 71.

Details

Redox score ?
64
PDB code
2nmm
Structure name
crystal structure of human phosphohistidine phosphatase
Structure deposition date
2006-10-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
20
Peptide accession
Q9NRX4
Residue number A
69
Residue number B
71
Peptide name
14 kDa phosphohistidine phosphatase

Ligandability

Cysteine 69 of 14 kDa phosphohistidine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 71 of 14 kDa phosphohistidine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within 14 kDa phosphohistidine phosphatase between cysteines 71 and 73. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2hw4
Structure name
crystal structure of human phosphohistidine phosphatase
Structure deposition date
2006-07-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
58
Peptide accession
Q9NRX4
Residue number A
71
Residue number B
73
Peptide name
14 kDa phosphohistidine phosphatase

Ligandability

Cysteine 71 of 14 kDa phosphohistidine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 73 of 14 kDa phosphohistidine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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