ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Rho GTPase-activating protein 35

Intramolecular
Cysteine 31 and cysteine 37
Cysteine 37 and cysteine 39
A redox-regulated disulphide may form within Rho GTPase-activating protein 35 between cysteines 31 and 37. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6d4g
Structure name
n-gtpase domain of p190rhogap-a
Structure deposition date
2018-04-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
64
Peptide accession
P81128
Residue number A
31
Residue number B
37
Peptide name
Rho GTPase-activating protein 35

Ligandability

Cysteine 31 of Rho GTPase-activating protein 35

Cysteine 37 of Rho GTPase-activating protein 35

A redox-regulated disulphide may form within Rho GTPase-activating protein 35 between cysteines 37 and 39. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6d4g
Structure name
n-gtpase domain of p190rhogap-a
Structure deposition date
2018-04-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
88
Peptide accession
P81128
Residue number A
37
Residue number B
39
Peptide name
Rho GTPase-activating protein 35

Ligandability

Cysteine 37 of Rho GTPase-activating protein 35

Cysteine 39 of Rho GTPase-activating protein 35

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