ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cysteinyl leukotriene receptor 2

Intramolecular
Cysteine 31 and cysteine 279
Cysteine 111 and cysteine 187
Cysteine 259 and cysteine 299
A redox-regulated disulphide may form within Cysteinyl leukotriene receptor 2 between cysteines 31 and 279.

Details

Redox score ?
88
PDB code
6rz6
Structure name
crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2570366 (c2221 space group)
Structure deposition date
2019-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
37
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NS75
Residue number A
31
Residue number B
279
Peptide name
Cysteinyl leukotriene receptor 2

Ligandability

Cysteine 31 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteinyl leukotriene receptor 2 between cysteines 111 and 187.

Details

Redox score ?
84
PDB code
6rz8
Structure name
crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2080365
Structure deposition date
2019-06-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9NS75
Residue number A
111
Residue number B
187
Peptide name
Cysteinyl leukotriene receptor 2

Ligandability

Cysteine 111 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cysteinyl leukotriene receptor 2 between cysteines 259 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6rz6
Structure name
crystal structure of the human cysteinyl leukotriene receptor 2 in complex with ono-2570366 (c2221 space group)
Structure deposition date
2019-06-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
92
Peptide accession
Q9NS75
Residue number A
259
Residue number B
299
Peptide name
Cysteinyl leukotriene receptor 2

Ligandability

Cysteine 259 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Cysteinyl leukotriene receptor 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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